Panama City 5-star Hotels
Compare rates for 5-star hotels in Panama City, Panama from hundreds of popular travel sites on HotelsCombined.
Panama City, Panama
1 May — 2 May2
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Travel insights for hotels in Panama City
Use our HotelsCombined data-powered tips to help you find your next hotel in Panama City.
What is the cheapest month to book a hotel in Panama City?
The cheapest month to book a hotel in Panama City is September (£74). Conversely, the most expensive month to stay in Panama City is January (£122).
What is the cheapest day to stay in a hotel in Panama City?
The cheapest day to stay in Panama City is Wednesday (£81). On the other hand, travelers can expect to pay the most on Tuesday, when the average nightly price is £113.
How much is a hotel in Panama City tonight?
Users have found prices for hotels in Panama City tonight starting as low as £13, rising to an average cost of £94, based on searches in the last 72 hours. Prices start from £33 for a 4-star hotel in Panama City for tonight.
How much is a Panama City hotel room this weekend?
In the past 72 hours, we’ve seen prices for hotels in Panama City this weekend for as little as £13/night. If you’re specifically looking for a 3-star hotel this weekend, our users have found prices as low as £13/night. For a 4-star hotel in Panama City, the cheapest rate recently found was £31/night for this weekend.
How far ahead should you book a hotel in Panama City?
Save money by booking a hotel at least 70 days before your trip to Panama City. The lowest price found when booking 70 days ahead was £11 per night.
Cheapest 5-star hotels in Panama City
Discover affordable 5-star hotels in Panama City that provide a quality experience without breaking the bank. 5-star hotels in Panama City can be found for as little as £65 per night. Price data was last updated on 24 April 2025
These are the lowest-priced 5-star hotels our users have recently found in Panama City. Prices may vary based on dates selected and hotel location.
Show all 19 5-star hotels
Ave Eusebio Morales Esquina, Panama City, Panama
0.2 mi from city centre
Free Wi-Fi
Parking
£65
Avg. per night
£76
Avg. per night
£85
Avg. per night
083500257 Avenida Aquilino de la Guardia (C/ Aquilino de la Guardia) Panama City, Panama, Panama City, Panama
0.2 mi from city centre
Free Wi-Fi
£115
Avg. per night
Calle Punta Colon, Punta Pacifica, Panama City, Panama
1.4 mi from city centre
Free Wi-Fi
£121
Avg. per night
£137
Avg. per night
£147
Avg. per night
Balboa Ave. And Aquilino De La Guardia, Panama City, Panama
0.6 mi from city centre
Free Wi-Fi
£170
Avg. per night
Santa Maria Boulevard, Panama City, Panama
5.9 mi from city centre
Free Wi-Fi
£172
Avg. per night
47th Street & Uruguay Street, Panama City, Panama
0.5 mi from city centre
Free Wi-Fi
£189
Avg. per night
Calle Primera Oeste, Panama City, Panama
2.3 mi from city centre
Free Wi-Fi
£225
Avg. per night
Other star-rated hotels in Panama City
Hotels that are booked the most in each class receive the “Most popular” badge. Hotels with the “Best value” have the most attractive prices based on their popularity. Price data was last updated on 24 April 2025.
Not set on a 5-star hotel? We’ve got plenty of other options for you to choose from. These are the most popular and best value properties in Panama City based on hotel class.
4 stars
Vía Tocumen Tocumen 0819-09190 PA, Panama City, Panama
£73
Calle 53 Marbella y Avenida 5a B Sur, Panama City, Panama
£35
3 stars
Via Argentina y Jose Marti, 17, Panama City, Panama
£31
2 stars and under
Calle Enrique Malek, Panama City, Panama
£29
Other accommodations in Panama City
Find deals on places to stay in Panama City that are not hotels. These are just a few of the most popular hostels and vacation rentals in the area. Pricing information was last updated on 24 April 2025.
Looking for something less traditional for your stay? Find the perfect hostel or vacation rental for your trip in Panama City.
Show all 1,085 stays
083500257 Avenida Aquilino de la Guardia (C/ Aquilino de la Guardia) Panama City, Panama, Panama City, Panama
0.2 mi from city centre
Free Wi-Fi
£115
Avg. per night
£76
Avg. per night
£147
Avg. per night