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Hotels in Otay Mesa, San Diego

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Travel insights for hotels in Otay Mesa

Use our HotelsCombined data-powered tips to help you find your next hotel in Otay Mesa.

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is December (£55). Conversely, the most expensive month to stay in Otay Mesa is April (£103).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Thursday (£83). On the other hand, travelers can expect to pay the most on Wednesday, when the average nightly price is £114.
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Cheapest hotels in Otay Mesa, San Diego

Discover affordable stays in Otay Mesa that provide a quality experience without breaking the bank. Hotels in Otay Mesa can be found for as low as £90 per night. There is currently one property in Otay Mesa that can be booked for this price. Quality Suites San Diego Otay Mesa is one of the hotels that can be booked for the lowest price in Otay Mesa. Price data was last updated on 7 August 2025
Currently, these are the lowest-priced hotels in Otay Mesa we've come across for the dates selected. Prices can differ depending on the dates selected, so use the search form to browse more options if you have flexibility.
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States
16.6 mi from city centre
Free Wi-Fi
Parking
£90
Avg. per night
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Holiday Inn Express & Suites San Diego Otay Mesa By IHG
Holiday Inn Express & Suites San Diego Otay Mesa By IHG

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Ct, San Diego, CA, United States
16.7 mi from city centre
Free Wi-Fi
£106
Avg. per night
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Where to stay in Otay Mesa

Explore different neighbourhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on 7 August 2025.
Use the map to find hotels in Otay Mesa that are close to the points of interest you'll be frequenting. As an added benefit, users can click a hotel they're interesting in to find helpful information and deals for that hotel.

Facts about staying in Otay Mesa, San Diego

Find useful tips and insights about staying in Otay Mesa to help you make the most of your experience. FAQs were last updated on 7 August 2025.

  • What are the best hotels in Otay Mesa?

    Otay Mesa is home to many highly-rated hotels, one of which is Holiday Inn Express & Suites San Diego Otay Mesa By IHG, which has a current rating of 7.5.

  • What is a good hotel near San Diego Convention Center?

    With a rating of 8.7/10 from 3,417 reviews, Manchester Grand Hyatt San Diego is a hotel close to San Diego Convention Center that is highly recommended by HotelsCombined users.

  • What is a good hotel in Otay Mesa near Mission Beach?

    The most popular hotel near Mission Beach is Paradise Point Resort & Spa, with 1,872 HotelsCombined users scoring it 8.1/10.

  • Is there a good hotel near B Street Cruise Ship Terminal?

    3,417 HotelsCombined reviews of Manchester Grand Hyatt San Diego score it 8.7/10, making it a highly recommended hotel near B Street Cruise Ship Terminal.

  • How much is a cheap hotel in Otay Mesa?

    Prices for Otay Mesa hotels have been found for as low as £85/night over the last 3 days.

  • What are the most popular landmarks to visit in Otay Mesa?

    There’s so much to see and do in Otay Mesa, but we’ve found that the most popular landmarks are San Diego Convention Center, Mission Beach, and B Street Cruise Ship Terminal. You’ll want to stay in San Diego to visit San Diego Convention Center, San Diego to visit Mission Beach, and San Diego to visit B Street Cruise Ship Terminal.

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Find better results for your stay in Otay Mesa

Search cheap hotels with HotelsCombined. Use the hotel finder to search for the cheapest hotel deal for all major destinations around the world. HotelsCombined searches hundreds of hotel booking sites to help you find hotels and book the ones that suit you best. Since HotelsCombined searches many hotel sites at once, you can find discounted hotels quickly, including Hotels Under £38 and Hotels Under £75. Discover hotel discounts now and make your hotel reservation today.