Casco Antiguo is the geographic and cultural city centre of Seville, Andalusia, Spain. The Guadalquivir river flows along its westernmost border while Macarena sits to the north and Distrito Sur to the south. Casco Antiguo boasts the most significant attractions of the city including multiple UNESCO World Heritage Sites.

The dominant features of the region are the Cathedral of Seville, which includes the prominent bell tower the Giralda and the Archivo General de Indias housing a collection of over 43,000 documents detailing the history of Spain, all of which are heritage sites. Other notable attractions include the tomb of Christopher Columbus and the Metropol Parasol. The primary campus of the University of Seville is also encompassed by Casco Antiguo.

Transportation around the region is served by the TUSSAM bus network and Seville Metro that run extensive routes through the city centre. The MetroCentro tramway has five stops, most of which are located in Casco Antiguo. Bicycling and walking are encouraged forms of transit between nearby points of interest.

The significant buildings located in Seville’s city centre collectively serve as architectural monuments to the different colourful eras of Spanish history. From the Moorish Era, Castilian Rule and the Golden Age to the 21st century, the representative auras emanate out of the stylistic edifices dominating every corner and corridor.